Urticaria pigmentosa
Urticaria pigmentosa forma herî gelemperî ya mastosîtoza çermê ye. Ew nexweşiyek hindik e ku ji ber hejmareke zêde ya mastxaneyên di çerm de çêdibe; dema ku aciz dibin, li ser çerm birîn an birîn çêdikin. Xalên sor an qehweyî bi gelemperî li ser çerm, di dora sîng, eniyê û piştê de têne dîtin. Van xaneyên mastê, dema ku aciz dibin (mînakî bi şuştina çermê, rûbirûbûna germê), hîstamîn pir zêde çêdikin; ev reaksiyona alerjîk dibe sedema mêşên li devera acizbûnê, ku carinan wekî “nîşana Darier” tê binav kirin.
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ReferencesMastocytosis rewşek e ku tê de zêde hucreyên mast hene, ku pir caran di beşên cûda yên laşê de, mîna çerm, mêjûya hestî û pergala digestîv tê dîtin. Li gorî Rêxistina Tenduristiyê ya Cîhanê (WHO), cutaneous mastocytosis dikare li sê celebên sereke were categorîzekirin. Tîpa yekem (mastocytomas) ji birînên bitenê an çend (≤3) pêk tê. Cureya duyemîn (urticaria pigmentosa) birînên pirjimar vedihewîne; bi gelemperî ji 10‑an zêdetir heya 100‑an kêmtir in. Cureya paşîn tevlêbûna berfireh li seranserê çerm nîşan dide. Urticaria pigmentosa forma herî gelemperî ya mastosîtoza çerm di zarokan de ye, lê ew dikare di mezinan de jî çêbibe. Ew bi gelemperî rewşek bê zirar e ku pir caran di dema xortaniyê de baştir dibe. Berevajî mastosîtoza mezinan, urticaria pigmentosa kêm‑kêm bandorê li organên hundur dike. Taybetmendiyek diyarker a urticaria pigmentosa meyla wê ye ku dibe sedema lekeyên piçûk, xiş, sor‑qehweyî, an zer‑qehweyî, an birînên li ser çerm, ku bi gelemperî wekî mêşok têne zanîn. Van deqan bi gelemperî di zaroktiyê de xuya dibin û dikarin di tevahiya jiyanê de bimînin.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Keçek 6-salî bi çend lekeyên rengê tarî ve hat hundur, ku pêşî li ser serê wê xuya bûn û piştre li ser rû û laşê wê di şeş mehên borî de belav bûn. Wê behs kir ku dema ku zext tê kirin, hest dikin ku ew radîbin, sor dibin û xiş dibin. Wê tecrubeya sorbûn, vereşîn, îshal an xişandinê nebû, û dîroka wê ya bijîjkî ya kesane û malbatî îşaretên têkildar peyda nekir. Li ser muayeneyê, me serê wê, eniya, rû û stûyê wê, û deqên tarî yên hinekî bilindkirî li ser sîng û pişta wê dîtin; gelek deqên tarî jî hene. Bi sivikî xişandina deqan di nav 2 hûrdeman de biwerimîn û xiş kirin, lê nîşanên di nav 15‑20 hûrdeman de winda bûn (Darier's sign).
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
